Recent years have seen a significant increase in the utilization of rotational viscoelectric global hemostasis testing in point-of-care settings in support of complicated surgical procedures and trauma. The current instruments allow near real-time data gathering, with many results being available…
Numerical platelet determination is a critical step in assessing bleeding and thrombosis risk. Additionally, platelet count serves as a biomarker for a number of pathologic states. Modern automated hematology analyzers produce fast, accurate, and precise platelet determination under most circumstances.…
Decreased fibrinogen concentration or impaired fibrinogen function can lead to hemorrhage. Thus fibrinogen testing is frequently utilized in the setting of trauma, surgery, disseminated intravascular coagulopathy, and fibrinolytic treatment to determine the need for replacement product. Congenital decreases in fibrinogen…
Along with prothrombin time (PT), activated partial thromboplastin time (PTT) serves as a common screening test for coagulation factor deficiencies. The test is sensitive to significantly decreased activities of so-called intrinsic (FXI, FIX, FVIII), common (FX, FV, FII, and fibrinogen),…
Prothrombin time (PT) was one of the first generated in vitro tests of the hemostasis system. It measures the time to form a fibrin clot in platelet-poor plasma stimulated with high amount of tissue factor (TF) and anionic phospholipid at the…
The human hemostasis system is complex and tightly regulated. The maintenance of adequate blood flow, interrupted only by formation of temporary thrombi localized to places of injury, requires coordination between endothelium, platelets, white blood cells, and numerous soluble plasma elements.…
von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting as much as 1% of the general population. The VWF (von Willebrand factor) protein has three essential hemostatic functions: (1) binding to FVIII thereby prolonging its half-life, (2)…
Hemostasis means stopping blood loss or bleeding. Hemostasis is an orchestrated, balanced, and tightly regulated process. Hemostasis can be subdivided into three sequential processes: primary hemostasis, secondary hemostasis and tertiary hemostasis. In primary hemostasis the interaction of the injured endothelium…