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Introduction According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the essential feature of a substance use disorder is a cluster of cognitive, behavioral, and physiologic symptoms whereby an individual continues to use a substance despite significant substance-related…

Key Points Kaposi's sarcoma is a multicentric, mostly oligoclonic neoplastic proliferation of endothelial cells that have been infected and transformed by human herpesvirus-8. Four epidemiologic types of Kaposi's sarcoma are recognized: classic (typically found sporadically in elderly persons of Mediterranean…