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INTRODUCTION History of Disease Pertussis (whooping cough) is a bacterial respiratory infection caused by Bordetella pertussis, a Gram-negative bacillus. Its major manifestation is a protracted cough that lasts many weeks, marked by characteristic intense paroxysms that often terminate in an…
The combining of multiple antigens into a single vaccine is not a new concept; combination vaccines have long been a bedrock of immunization programs. Since the early 1990s, we have transitioned from a world in which DTP (diphtheria, tetanus, and…