Menna R. Clatworthy Archives

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mTOR Inhibitors: Sirolimus and Everolimus

Sirolimus and its closely related analog everolimus are potent immunosuppressive agents that impair lymphocyte activation and proliferation by inhibiting the mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin. The mTOR inhibitors emerged in the 1990s…

The Immunology of Transplantation

Introduction Solid organ transplant requires the removal of an organ from one individual, the donor, and its placement in the recipient. Whether the donor is living or deceased, this process inevitably requires a temporary cessation of circulation and hence oxygenation,…