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Key Points Atrial fibrillation (AF) is associated with substantial morbidity and mortality due to stroke and systemic embolism. The left atrial appendage (LAA) appears to be the primary source of thromboembolism in AF and therefore is a target for mechanical…
Key Points Dual-antiplatelet therapy (DAPT) with aspirin and a P2Y 12 receptor inhibitor is the cornerstone of therapy after percutaneous coronary intervention (PCI) with stents. The thienopyridines—ticlopidine, clopidogrel, and prasugrel—are P2Y 12 inhibitors that are prodrugs and therefore require conversion…