Matthew F. Kalady Archives

Physical Address

304 North Cardinal St.
Dorchester Center, MA 02124

Inherited Colorectal Cancer and the Genetics of Colorectal Cancer

Colorectal cancer (CRC) is a complex heterogeneous disease with a variety of factors influencing genetic and epigenetic changes that drive tumor initiation and progression. Alterations in the intricate system of biological checks and balances can lead to a malignant change…

Hereditary Nonpolyposis Colorectal Cancer and Lynch Syndrome

Introduction Approximately 5% of all colorectal cancers (CRCs) are associated with a hereditary syndrome, where a germline mutation in a key tumor suppressor or DNA repair gene produces a cancer predisposition that can be inherited. Hereditary nonpolyposis colorectal cancer (HNPCC)…