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Amyloidosis is a deposition disease in which proteins with unstable structures misfold and aggregate into amyloid fibrils, which deposit in the heart, kidneys, liver, peripheral nerves, gastrointestinal tract, lungs, and soft tissues. Amyloid fibrils are insoluble nonbranching structures 7 nm…

Additional content is available online at Elsevier eBooks for Practicing Clinicians The systemic amyloidoses are a group of diseases characterized by the extracellular deposition of insoluble, misfolded fibrillar proteins in the form of β-pleated sheets, resulting in organ dysfunction. First…