Tumor-Like Conditions Fibroepithelial–StromAl Polyp (Pseudosarcoma Botryoides) Definition A benign polypoid growth that arises from the distinctive subepithelial stroma of the distal female genital tract. Clinical Features Fibroepithelial–stromal polyps, which are hormonally sensitive, most commonly occur in the vulvovaginal region of…
Metastatic Tumors Involving the Ovary Metastases account for approximately 8% of malignant ovarian neoplasms in women undergoing surgery for an adnexal mass in the United States. Metastases derived from nongynecologic sites are 11 times more common than those originating from…
This category includes a diverse group of neoplasms believed to derive from the hormone-producing ovarian cortical stroma. Based on their predominant cell population and appearance, the World Health Organization (WHO) classification divides them into two main categories: (1) pure lesions,…
Introduction The conditions presented in this chapter represent a wide spectrum of physiologic and pathologic endometrial changes. Their proper identification is important to exclude malignancy and provide correlation with the clinical context. A list of simplified evidence and consensus-based terminology…
Introduction Mesenchymal lesions that occur in the vulva and vagina can be separated into two general categories: (1) those that are relatively site-specific, i.e., they may occasionally occur at extragenital sites; and (2) those that occur more commonly at other…
Introduction Histogenesis Stromal and sex cord–stromal tumors of the ovary constitute a diverse collection that is derived from the ovarian cortical stromal and hilar cells ( Fig. 27.1 ). These cells form during embryogenesis as condensations of subcoelomic mesenchyme, in…
Epithelial Tumors Tumor Origin, Terminology, and Classification This chapter addresses pelvic epithelial malignancies that are commonly held synonymous with “ovarian cancer.” To maintain consistency, the term ovarian will be used as a generic term but this category encompasses tumors that…
Introduction The practice of gynecologic pathology often entails the evaluation of abnormalities in the peritoneal cavity and determination of their relationship to the reproductive tract. This exercise requires that the pathologist distinguish which peritoneal disorders are müllerian derived versus originating…
Introduction Definition Uterine mesenchymal tumors are neoplasms derived from or differentiating toward mesodermally derived tissues. Differentiation is typically toward normal constituents of the uterine corpus—endometrial stromal and myometrial smooth muscle cells. However, differentiation toward heterologous tissues—that is, mesenchymal tissue not…
Introduction This chapter addresses endometrial carcinomas, including those with mesenchymal differentiation (carcinosarcomas). Primary endometrial carcinomas constitute a range of morphologies, including carcinomas closely resembling preexisting endometrial epithelium (endometrioid), clear cell carcinomas, uterine serous carcinomas (USCs; also referred to as uterine…