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Summary of Key Points Biomarker development has profoundly affected basic understanding of carcinogenesis and expanded means of intervention in human cancers. Biomarkers have been applied with variable success in three broad areas that correspond to phases of tumor development and…
Summary of Key Points Lung cancers commonly have structural chromosome aberrations and aneuploidy, with many of them associated with carcinogenesis. Gene amplification is a common mechanism of oncogenic activation in nonsmall cell lung cancer (NSCLC) involving genes such as MYC…