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The immune system, the function of which is to protect against infections, is composed of two branches: a phylogenetically earlier one called innate immunity and a more recently evolved one called adaptive immunity. Innate and adaptive immunity are not two…

Although all the disorders in this chapter represent inflammatory systemic diseases, there are two major groups based upon underlying pathomechanisms. Disorders such as systemic-onset juvenile idiopathic arthritis (Still disease) and inherited autoinflammatory diseases are related to abnormalities in the innate…