Over 350 molecular defects that result in primary immune deficiency are known to date. Many of these gene defects have been identified in recent years with the advent of whole-exome and whole-genome sequencing. The study of patients with primary immune…
Over 350 molecular defects that result in primary immune deficiency are known to date. Many of these gene defects have been identified in recent years with the advent of whole-exome and whole-genome sequencing. The study of patients with primary immune…
Immune compromise arises either as a heritable genetic defect (primary immune deficiency diseases, PIDDs) or as a consequence of another pathologic process such as infection, malignancy, malnourishment, or iatrogenic immunosuppression (secondary immune deficiencies). Immune dysfunction in patients with PIDDs is…