Key Points: Acne 1. In acne, the pilosebaceous unit is the target of disease. The microcomedone is the earliest lesion. 2. Combination therapy including a retinoid plus benzoyl peroxide or an antimicrobial agent is the preferred approach for almost all…
Acknowledgments The author wishes to acknowledge the contribution of prior authors, Melissa D. Darling, MD, and James W. Patterson, MD Key Points: Panniculitis 1. Given the similar clinical appearance among panniculitides, histopathologic characterization is often critical for a correct diagnosis.…
1 Are some disorders of pigmentation markers for systemic disease? Yes. Examples include the following: Generalized depigmentation: Albinism. Generalized hyperpigmentation: Addison's disease. Ash-leaf hypopigmented macules: Tuberous sclerosis. Axillary and inguinal freckles: Neurofibromatosis. Lentigines: Peutz-Jeghers syndrome. 2 How do you diagnose…
Acknowledgments The author wishes to acknowledge the contributions of the previous authors, Lisa E. Maier, MD, and Lori Lowe, MD. Key Points: Cutaneous Deposition Disorders 1. Amyloid deposition can result in both localized and systemic disease. 2. Pretibial myxedema is…
1 A patient presents to your office with a 10-page typed-out medical history. She states that she is “allergic” to 20 different medicines. Is she likely to have drug allergies or drug intolerances to most of these drugs? Drug intolerances…
1 What is meant by “granulomatous diseases of the skin”? Granulomatous disorders of the skin comprise a broad category of diseases that are characterized by the accumulation of activated macrophages with an epithelioid appearance in the dermis or subcutaneous tissue.…
1 What are the ichthyosiform dermatoses? The ichthyosiform dermatoses are a heterogeneous group of disorders presenting with excessive scaling of the skin. The inherited forms of the ichthyoses are most common, although the condition can occur secondary to other diseases.…