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1 What infectious agent plays a central role in the development of most post-transplant lymphoproliferative disorder and why? Epstein-Barr virus (EBV), a ubiquitous human herpesvirus transmitted primarily via saliva, is causally involved in most lymphoproliferative disease. Initial infection with EBV…
1 What percent of childhood cancer is attributable to inherited mutations? In a recent study of 1120 children and adolescents with cancer, germline mutations in cancer-predisposing genes were identified in 8.5% of the cases. With the exception of this small…