Introduction Normal lymphoid precursors undergo somatic recombination at their immunoglobulin (Ig) or T-cell receptor (TCR) gene loci, and the successful completion of V(D)J recombination, with the resultant formation of a functional Ig or TCR, is required for the survival of…
Introduction Normal lymphoid precursors undergo somatic recombination at their immunoglobulin (Ig) or T-cell receptor (TCR) gene loci, and the successful completion of V(D)J recombination, with the resultant formation of a functional Ig or TCR, is required for the survival of…
The acute leukemias of childhood are rare diseases that collectively represent about 30% of malignancies in children younger than age 15 years. Approximately 3000 new cases of childhood leukemia occur annually in the United States, 80% of which are acute…