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Definition Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disorder characterized by generalized lymphadenopathy, hepatosplenomegaly, constitutional symptoms, rash, anemia, and polyclonal hypergammaglobulinemia. Histologically, the normal architecture of the lymph node is effaced by a polymorphic cellular infiltrate composed of lymphocytes,…
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus with tropism for B cells. More than 90% of humans are infected with EBV, and the infection persists for life. Usually primary infection is asymptomatic and occurs early in life, and when symptomatic…