Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports Courtesy Iris Aronson Open full size image Epidermolysis bullosa acquisita (EBA) is an uncommon,…
Key points Less than 50% of patients affected with atopic dermatitis have a genetic mutation of the skin barrier protein, filaggrin. Thus additional contributing factors, barrier defects, and beyond could account for disease triggering of the other 50% of patients…
Key points Cutaneous microcirculation, a type of microvasculature situated just below the epidermis, is composed of major components of blood vessels (arterioles and venules) and lymphatic vessels. The cutaneous blood vessels are organized into a superficial plexus near the dermal-epidermal…
Key points Epidermis is the outermost layer of skin surface that forms the first line of defense against invaders from the environment. Keratinocyte is the epidermis’s principle cell type responsible for generating and maintaining the integrity of the epidermis. Besides…
Key points The fact that up to 50% of atopic dermatitis (AD) patients have loss-of-function genetic mutations of skin barrier protein filaggrin points to a cutaneous weakness that allows external factors to trigger skin inflammation in AD. Various studies documented…
Key points Atopy of the skin is manifested as atopic dermatitis (atopic eczema). Histologically, the atopy of the skin is characterized by epidermal and dermal infiltration predominantly by lymphocytic cells as well as eosinophils and mast cells. In some patients,…
Key points Although the original term atopy provides a general framework of understanding about allergic clinical conditions, this big umbrella now includes a group of patients who have heterogeneous clinical and laboratory-defined characteristics. Similarly, atopic dermatitis , the skin atopy,…