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Acknowledgments Some passages in this chapter were taken directly or slightly modified from the predecessor chapter entitled “Genetically Engineered Animals in Product Discovery and Development” as printed in Haschek and Rousseaux's Handbook of Toxicologic Pathology , 3rd edition, by permission…

1 Introduction Throughout modern biomedical research, the rabbit has remained a core laboratory animal species. Studies using rabbits have provided important insights into toxicology, immunology, reproduction, and other fields. Interestingly, despite their common use, many key factors about rabbit biology,…