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For many years, researchers suspected that hereditary coagulation defects underlie a large percentage of venous thromboembolic events that could not be attributed to identifiable acquired risk factors. Acquired risk factors for venous thrombosis consist of a heterogeneous group of conditions…
Rare bleeding disorders consist of inherited quantitative or functional deficiencies of factors I (fibrinogen), II, V, VII, X, XI, and XIII; combined factor deficiencies, particularly of factors V and VIII; inherited quantitative or functional deficiencies of vitamin K–dependent factors; and…