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Key Points Vascular disease is a major cause of dementia in the elderly. White matter is vulnerable to ischemic damage with oligodendrocytes targeted by hypoxia. The neurovascular unit in the white matter includes the oligodendrocytes that myelinate axons. Microglia impact…
Key Points Most ischemic strokes involve both white matter and gray matter, and 20% of strokes predominantly involve white matter. Mechanisms of white matter ischemic injury are less well understood than the mechanisms of gray matter ischemic injury and distinctly…