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Central Sympathetic Agents and Direct Vasodilators
Mechanism of Action Central sympatholytics (e.g., methyldopa, guanabenz, guanfacine, clonidine, moxonidine, and rilmenidine) have a variety of antihypertensive actions that result in increased sodium excretion and decreases in the cardiac output, heart rate, total peripheral resistance, and renin release. Central…