General Overview and Incidence Incidence varies depending on the institution, patient population, allograph types, and immunosuppression regimes. Etiology/Histopathology Clinical settings causing immune dysfunctions, such as viral Epstein-Barr virus (EBV) infection, human viral immunodeficiency, autoimmune disease, and posttransplantation, can cause clonal…
General Overview and Incidence Pediatric hematology/hematopathology spans the spectrum of benign, malignant, and neoplastic mimickers. Neoplastic lymphoid, myeloid, and histocytic neoplasms follow criteria in the updated World Health Organization (WHO) 2017 classification similar to adults. Examples of common entities or…
General Overview and Incidence Precursor lymphoid neoplasms or acute lymphoblastic leukemia (ALL) is the second most common leukemia affecting adults with about 1.6 per 100,000 and 6500 cases per year in the United States. In 2018, an estimated 5960 new…
A Brief Overview of Acute Myeloid Leukemia Acute myeloid leukemia (AML) is understood to be the product of genetic and epigenetic changes within a multipotent myeloid stem/progenitor cell that generate and amplify a clone capable of differentiation arrest and uncontrolled…
General Overview and Incidence Mastocytosis is no longer under the broad category of myeloproliferative neoplasm (MPN). Mastocytosis is a heterogeneous disease of clonal neoplastic proliferation and expansions of mast cells (MCs) that are CD117 + /CD25 + /CD2 + and…
General Overview Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by abnormal chronic proliferation of cells belonging to myeloid lineages that are often associated with elevated blood counts, splenomegaly, and a propensity for thrombosis. The World Health Organization (WHO)…