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Potassium-Sparing Diuretics
Questions 1 How do potassium-sparing diuretics work? Potassium-sparing diuretics block the reabsorption of sodium through the epithelial sodium channel (ENaC) in exchange for potassium in the connecting tubule (CNT) and collecting duct (CD). Traditional potassium-sparing diuretics (amiloride, triamterene) directly block…