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Introduction The pathogenic model of hidradenitis suppurativa (HS) may be in the midst of a paradigm shift, balancing the initial model of a disorder of (primary) follicular occlusion with consideration as an autoinflammatory keratinization disease (AiKD). There is observational, experimental,…

Key points There are three major types of epigenetic modifications: DNA methylation, microRNAs, and posttranslational histone modifications. DNA methylation and microRNAs alter the expression of atopic dermatitis-associated genes identified in multiple genomewide association studies. Epigenetic alterations also impact epidermal barrier…