JOHN P. KINSELLA Archives

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Pathophysiology of Meconium Aspiration Syndrome

Introduction Meconium aspiration syndrome (MAS) follows fetal hypoxic/ischemic stress that leads to intestinal peristalsis, meconium release, contamination of the amniotic fluid, and gasping respirations, which causes aspiration of noxious meconium-stained fluid deep into the fetal lung. Aspiration of meconium manifests…

Pulmonary Gas Exchange in the Developing Lung

Introduction Integral to the system of pulmonary gas exchange are mechanisms to maintain matching of pulmonary perfusion and alveolar ventilation, known as ventilation / perfusion matching . The goal is that alveolar oxygen and pulmonary capillary blood have intimate contact…

Acute Neonatal Respiratory Disorders

Key Points Marked hypoxemia in the newborn can be caused by parenchymal lung disease, pulmonary vascular disease, or congenital heart defects. Events occurring at delivery, as well as the response to supplemental oxygen and to continuous positive airway pressure, can…