Blisters, which are clinically subdivided into vesicles (L. vesicula , dim. of vesica , bladder) and bullae (L. bubble), are defined as accumulations of fluid either within or below the epidermis and mucous membranes. Although somewhat arbitrary, the term ‘vesicle’…
Specimen fixation, grossing/put-through, processing, embedding and sectioning The aim of fixation is to maintain clear and consistent lesional features and to preserve tissue in an optimal state suitable for a range of staining and ancillary histopathological techniques. Most fixation methods…
Introduction Skin is a double-layered membrane covering the exterior of the body and consists of a stratified cellular epidermis and an underlying dermis of connective tissue. In adults, the skin weighs over 5 kg and covers a surface area approaching 2 m…