General information Guancydine is a vasodilator that has been used to treat hypertension [ ]. It inhibits the actions of angiotensin, reducing its effects on the urinary excretion of water, sodium, potassium, and calcium [ ]. Because it is a…
General information Griseofulvin was originally isolated in 1939 as a natural product of Penicillium griseofulvum [ ]. It interferes with fungal microtubule formation, disrupting the cell’s mitotic spindle formation and arresting the metaphase of cell division. Griseofulvin is a fungistatic…
See also Fluoroquinolones General information Grepafloxacin is a synthetic fluoroquinolone antibiotic with extensive tissue distribution and strong antibacterial activity in vivo [ , ]. However, it was withdrawn in 1999 because of its adverse cardiovascular effects, which included dysrhythmias […
See also Myeloid colony-stimulating factors General information Granulocyte–macrophage colony-stimulating factor (GM-CSF) primarily increases the production and activity of neutrophils, and stimulates the proliferation of monocytes and eosinophils. Recombinant human forms of GM-CSF include molgramostim and sargramostim. Based on a retrospective…
See also Myeloid colony-stimulating factors General information Granulocyte colony-stimulating factor (G-CSF) primarily increases the production and function of neutrophils by stimulating the proliferation of committed myeloid precursors, rather than pluripotential stem cells [ ]. Recombinant human forms of G-CSF include…
General information Human chorionic gonadotropin (HCG, hCG), extracted from the urine of pregnant women, has mainly luteinizing hormone (LH) activity. Human menopausal gonadotropin (HMG, hMG) contains both follicle-stimulating hormone (FSH) and luteinizing hormone in about equal amounts. Where materials of…
General information The gonadorelin antagonists include abarelix, cetrorelix, degarelix, detirelix, ganirelix, iturelix, prazarelix, ramorelix, and teverelix. Gonadorelin agonists suppress the release of gonadotropin after an initial surge: pituitary suppression takes up to 2 weeks to develop. Competitive antagonists at gonadorelin…
General information Gonadorelin is gonadotropin-releasing hormone. The effects of gonadorelin depend on the duration of use. Gonadotropin release is stimulated in the short term, but is later suppressed owing to down-regulation of hypophyseal receptors. Its therapeutic indications have been summarized…
General information Gold is a heavy yellow-colored element (symbol Au; atomic no. 79). Its symbol derives from the Latin word aurum. It is usually found as the metallic element but can occur as salts such gold telluride (sylvanite). Auranofin is…
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