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Acknowledgments The editors gratefully acknowledge contributions by Drs. Peter Adamson, Richard Aplenc, Emily Lipsitz, and Kerice Pinkney, as well as from all of the previous authors, that were retained from prior editions of Pediatric Secrets . Chemotherapy and radiation therapy…
1 What is the chromosomal abnormality associated with chronic myeloid leukemia? The Philadelphia chromosome—or t(9;22)(q34.1;q11.2) resulting in a BCR-ABL1 fusion gene—is the hallmark of 90% to 95% of chronic myeloid leukemia (CML) cases. The remaining cases consist of variant and…