Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Development of the Hypothalamus-Pituitary-Adrenal Axis in the Fetus
Introduction The development of the hypothalamus-pituitary-adrenal (HPA) axis begins early in gestation. Corticotropin-releasing hormone (CRH) is synthesized and secreted into the hypophyseal portal circulation by the paraventricular nucleus of the hypothalamus. CRH acts on corticotroph cells in the anterior pituitary…