Tag Jeffrey M. Perlman

Neonatal and Perinatal Medicine

Neonatal Neurology in the Low-Resource Setting for the Term and Preterm Newborn

Introduction Prominent identified causes of brain injury in the low-resource setting (LRS) include hypoxic-ischemic encephalopathy (HIE)/neonatal encephalopathy (NE), germinal matrix–intraventricular hemorrhage (GMH-IVH) in the premature infant, prolonged neonatal seizures, neonatal hypoglycemia, and hyperbilirubinemia (kernicterus). The magnitude of the contributions of…

Volpe's Neurology of the Newborn
March 22, 2024

Neonatal and Perinatal Medicine

Preterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus

Germinal matrix–intraventricular hemorrhage (GMH-IVH) is the most common variety of neonatal intracranial hemorrhage and is characteristic of the premature infant. The importance of the lesion relates not only to its high incidence but also to the essential gravity of the…

Volpe's Neurology of the Newborn
March 22, 2024

Neonatal and Perinatal Medicine

Intracranial Hemorrhage: Subdural, Subarachnoid, Subpial, Intraventricular (Term Infant), Miscellaneous

Intracranial hemorrhage in the neonatal period is an important clinical problem. Its importance relates to a relatively high frequency of occurrence, accompanied at times by serious neurological sequelae or even death. Over the last decade there have been changes in…

Volpe's Neurology of the Newborn
March 22, 2024

Neonatal and Perinatal Medicine

General supportive management of the term infant with neonatal encephalopathy following intrapartum hypoxia-ischemia

Key points Early identification of the infant at risk for evolving hypoxic-ischemic brain injury and initiation of therapeutic hypothermia is critical in overall management. Glucose should be checked shortly after birth and corrected promptly as needed. Carbon dioxide should be…

Neurology: Neonatology Questions and Controversies
March 22, 2024

Neonatal and Perinatal Medicine

Intraventricular hemorrhage in the premature infant

Background Case history HW was a 500 g, 23-week premature twin B male infant born to a 34-year-old G1P0 (gravida 1, para 0) mother whose pregnancy was complicated by the onset of premature labor. The mother received a dose of…

Neurology: Neonatology Questions and Controversies
March 22, 2024