Key Points Large vessel occlusion (LVO) acute ischemic stroke (AIS) is a major cause of disability and mortality. Intravenous (IV) tissue plasminogen activator (tPA), approved nearly two decades ago for the treatment of AIS, has low rates of recanalization for…
Key Points A trial can be conducted only when there is equipoise. Phase 2 trials can reduce the number of ineffective treatments taken to phase 3 in stroke research. Common outcome measures are the National Institutes of Health stroke scale…
Key Points The technique of cerebral angiography emanates from before the advent of noninvasive imaging, yet this approach serves a unique role in the management of patients with cerebrovascular disorders. The risks and benefits of cerebral angiography include morbidity due…
An intracranial aneurysm is a cerebrovascular disorder in which weakness in the wall of a brain artery causes dilation or ballooning, which can grow and rupture over time. The term aneurysm originally comes from the Greek aneurysma—ana meaning “across” and…