Incidence The incidence of transfusion-related acute lung injury (TRALI) and deaths due to TRALI has decreased substantially over the past decade, as TRALI mitigation strategies have been implemented. In 2006, 35 TRALI-related fatalities were reported to the FDA. These accounted…
Incidence TACO is estimated to occur in up to 1% of transfusions, with higher rates reported in studies using active surveillance methodologies. For several reasons, TACO is likely one of the most underreported transfusion complications to hospital transfusion. A retrospective…
Platelet refractoriness is defined as an inappropriately low platelet count increment after platelet transfusion. There are nonimmune and immune causes for platelet refractoriness ( Table 57.1 ), with nonimmune causes being responsible for the majority of cases. Evaluation of the…
A doctrine introduced in 1945 by Jehovah’s Witnesses teaches that the Bible prohibits the consumption, storage, and transfusion of human blood (Genesis 9:3, 4 and Acts 15:19, 20). The Watch Tower Bible and Tract Society of Pennsylvania have issued many…
Transfusion in Patients Undergoing Hematopoietic Stem Cell Transplantation Human leukocyte antigen (HLA) compatibility is of greater importance than ABO compatibility in donor selection for HSC transplantation (HSCT). As such, ABO incompatibility may be present in up to 50% of donor/recipient…
Red Blood Cell Transfusions RBC Transfusion Considerations in Neonates Neonatal RBC transfusion thresholds are not clearly defined, with gestational age, postnatal age, and clinical condition being important considerations. Two randomized control trials (RCTs) (Bell et al. and Kirpalani et al.) comparing liberal…