Skin Barrier Matthias Schmuth Peter M. Elias Thomas J. Franz Jui-Chen Tsai Gopinathan K. Menon Kenneth R. Feingold Chapter Contents Stratum corneum structure and organization 2176 Epidermal metabolism and the skin barrier 2176 Impaired skin barrier and cutaneous inflammation 2179 The skin provides the largest interface…
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Benign Lymphocytic Infiltrates Lymphocytic Infiltrate of Jessner A benign skin-limited disorder that overlaps with other entities, including dermal lupus erythematosus, cutaneous lymphoid hyperplasia, and polymorphic light eruption (PMLE). Males = females; onset typically during middle age; very rare in children.…
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Spectrum of disorders caused by proliferation and accumulation of mast cells in the skin and/or other tissues ( Table 96.1 ). Table 96.1 WHO classification of mastocytosis. Cutaneous mastocytosis (CM) Maculopapular CM/“urticaria pigmentosa” Diffuse CM Mastocytoma (≤3 lesions) Systemic mastocytosis…
Neural/Neuroendocrine Neurofibroma Skin-colored to pink, soft papulonodule, often on the trunk (see Fig. 50.2 ). Compressible (the tumor often herniates inward upon palpation – this is referred to as the “button-hole” sign); it is sometimes pedunculated. Usually solitary in most…
Lesions of vascular origin are broadly, and somewhat imperfectly, classified as neoplasms (tumors), malformations, reactive proliferations, or telangiectasias. The growth of a neoplasm is largely autonomous (i.e. not reactive). Malformations, in general, are not actively proliferating (see Ch. 85 ).…
A malignant tumor of melanocytes, most commonly arising from cutaneous melanocytes; can also develop from melanocytes residing elsewhere – e.g. in the uveal tract, retinal pigment epithelium, gastrointestinal mucosa, or leptomeninges. Some cutaneous melanomas (CMs) arise de novo , whereas…