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Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
The porphyrias and the sideroblastic anemias are metabolic disorders that involve defects in heme biosynthesis. Most forms of porphyria are inherited in a Mendelian autosomal dominant pattern, but some types are recessive, and others are acquired through exposure to porphyrinogenic…