Questions 1 How do alpha-2 agonists reduce blood pressure? Norepinephrine activates the alpha-2 adrenergic receptor in the brain, which serves as a negative feedback mechanism to suppress the sympathetic nervous system. Drugs with alpha-2 agonist activity mimic this effect centrally,…
Questions 1 What are the acute aortic syndromes? Acute aortic syndromes (AAS) are a group of emergent aortic pathologies with similar clinical characteristics. AAS occur when blood penetrates the medial layer of the aorta either from a tear or ulceration…
1 What are the four main mechanisms by which drug-induced hypertension may occur? See Fig. 13.1 : Sympathomimetic activation Volume retention via mineralocorticoid activation Direct vasoconstriction via increased vasoconstrictors, decreased vasodilators, or upregulation of the angiotensin II receptor type 1 (AT…