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Neuromuscular Disorders Including Malignant Hyperthermia and Other Genetic Disorders
Key Points ▪ Malignant hyperthermia (MH) is a pharmacogenetic disorder inherited primarily in an autosomal dominant pattern. ▪ MH susceptibility is linked to 230 mutations in the skeletal muscle ryanodine receptor (RyR1) and four mutations in the calcium voltage-gated channel…