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Sepsis-Induced Acute Kidney Injury

Objectives This chapter will: 1. Review the epidemiology of sepsis-induced acute kidney injury. 2. Discuss the evidence supporting novel mechanisms leading to acute kidney injury in the setting of sepsis. 3. Review novel approaches to the diagnosis of sepsis-induced acute…

Hyperlactatemia and Lactic Acidosis

Objectives This chapter will: 1. Review the major factors that modulate physiologic lactate production and utilization. 2. Discuss the mechanisms that modulate lactate during critical illness. 3. Review acid-base aspects of lactic acidosis. 4. Review causes of lactic acidosis that…