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SUMMARY Simple analgesics such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) are highly effective clinically. The introduction of cyclooxgenase-2–inhibitory NSAIDs (coxibs), selective inhibitors of cyclooxygenase-2, has resulted in large quantities of safety and efficacy data. Although there are differences in…
SUMMARY Clinical trials for acute and chronic pain can achieve high levels of precision if they adhere to some simple rules. This chapter discusses the various ways in which pain may be studied, how trials may be designed, and how…