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Tag Gregory J. del Zoppo

The Neurovascular Unit and Responses to Ischemia

Key Points The neurovascular unit is a structural and functional concept that seeks to integrate microvessel events with those of the neurons, glia, and brain matrix and serves as a framework for fundamental and new findings (e.g., the glymphatic CSF…

Mechanisms of Thrombosis and Thrombolysis

Key Points The fundamental processes involved in thrombus formation, thrombus dissolution, and thrombus stability and their relevance to the central nervous system (CNS) are described. The role(s) of endogenous plasminogen activators (PAs, including tissue-type plasminogen activator, urokinase-type plasminogen activator) in…