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Introduction The introduction of prognostic and predictive markers in immunohistochemistry (IHC) has made a tremendous beneficial impact on patient diagnosis and management. In the 1940s the demonstration of tissue constituents using an antibody labeled with a fluorescent dye was first…

Introduction Transforming a tissue specimen from fixed material to stained sections is a multiple step process which began as separate manual tasks. Indeed, histology in the last century has been the slowest of the laboratory medicine departments to innovate and…