Overview Hepatocellular carcinoma (HCC) represents a challenging malignancy of global importance (see Chapter 89 ). It is the fifth most common solid tumor in terms of incidence and the third leading cause of cancer-related death worldwide. Its incidence mirrors that…
Summary of Key Points Liver Cancer There is a continued rise of hepatocellular carcinoma (HCC) incidence, especially in the Western hemisphere. HCC main risk factors are hepatitis B, hepatitis C, alcohol use, and nonalcoholic steatohepatitis. Screening programs continue to evolve…
Key points Cytotoxic chemotherapy has not proven effective in hepatocellular carcinoma (HCC). Sorafenib is the only approved agent for advanced, unresectable disease. Current studies are evaluating a wide range of targeted agents covering the spectrum of molecular aberrations in HCC.…