Key Concepts Renewal of the corneal epithelium results from limbal epithelial stem cells (LESCs) located at the basal layer of epithelium found at the corneoscleral limbus. The limbal stem cell niche has a crucial impact on LESC function and regulation.…
Key Concepts Herpes simplex virus (HSV) keratitis is one of the most common infectious causes of corneal blindness. HSV keratitis has multiple presentations that can be challenging for clinicians. The main corneal manifestations include infectious epithelial keratitis, neurotrophic keratopathy, necrotizing…
Key Concepts Ligneous conjunctivitis is a rare disorder associated with systemic plasminogen deficiency. Only type I hypoplasminogenemia (reduction in plasminogen level and activity) has been shown to cause any form of pseudomembranous disease. The most common manifestation of systemic plasminogen…