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Osteoclast-rich lesions of bone: a clinical and molecular overview
Learning points ⇒ The H3-3A.Gly34Trp (G34W) missense mutation is essentially pathognomonic of giant cell tumor of bone, occasionally to p.Gly34Leu (G34L) alterations. There are good antibodies available for detecting this mutation by immunohistochemistry. Malignant giant cell tumor of bone harbors…