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Acknowledgments We thank Drs. Linda D. Gillam, Konstantinos Koulogiannis, and Leo Marcoff for their contributions to the previous edition of this chapter. Transcatheter aortic valve replacement (TAVR) has emerged as a new option for the treatment of patients with severe…

Epidemiology of Chagas Disease First described by the Brazilian physician Carlos Chagas in 1909, Chagas cardiomyopathy is the result of a chronic myocarditis caused by infection with the parasite Trypanosoma cruzi. The chief mode of transmission is via the bite…

As the burden of heart failure (HF) and cardiomyopathies continues to rise, the clinical need for early detection of individuals at risk becomes critical. Identification of patients with a poor prognosis allows for early interventions (primary prevention, medications, devices) that…

Introduction and General Concepts There has been a dramatic change in the acute presentation, chronic consequences, and mode of death related to coronary artery disease (CAD) in the past few decades. The rapid recognition of acute coronary syndromes and increased…

When patients present with chest pain, the clinician needs to be alert and thorough in trying to determine its cause. The patient’s demographic characteristics together with a careful history should provide the initial information for understanding the likely etiologies. The…