Tag Elliott Richelson

Introduction Oral irreversible inhibitors of the intracellular enzyme, monoamine oxidase, have been in clinical use for over 60 years. As a group, they constitute the oldest class of antidepressants. The monoamine oxidase inhibitors (MAOIs) were developed decades ago out of…

Introduction As a group, the tricyclic antidepressants (TCAs) comprise the second-oldest class of antidepressants, beginning with the serendipitous discovery in the late 1950s that imipramine, investigated initially for its sedative properties, was effective for patients with severely depressed mood, marked…