This chapter reviews two aggressive large B-cell lymphomas composed of large cells with a predominant immunoblastic or plasmablastic morphology and the immunophenotype of plasma cells. Despite sharing these morphologic and immunophenotypical features, one of them, plasmablastic lymphoma (PBL), occurs in…
Definition In the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, the World Health Organization defines mantle cell lymphoma (MCL) as a mature B-cell neoplasm generally composed of monomorphic small to medium-sized lymphoid cells with irregular nuclei that carries…
Historical Background The classification of lymphoid neoplasms used in this text is the one published by the World Health Organization (WHO) in WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues . Initially published in 2008, the WHO's fourth edition…
Lymphoid tissues are the sites where precursor cells mature into immunocompetent lymphoid cells and where immune reactions to antigens occur. The lymphoid tissues and the stages of lymphocyte differentiation and maturation have an anatomy—they occur at specific sites in the…