Introduction and Historical Background The classification of malignant lymphomas has undergone significant changes over the past 50 years. The current approach is based on the integration of morphologic, phenotypic, genetic, and clinical features that allows the identification of distinct disease…
Introduction and Historical Background The classification of malignant lymphomas has undergone significant changes over the past 50 years. The current approach is based on the integration of morphologic, phenotypic, genetic, and clinical features that allows the identification of distinct disease…
Definition Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell neoplasm pathogenetically linked to human T-lymphotropic virus 1 (HTLV-1; also called human T-cell leukemia virus ). This is the first retrovirus proved to cause a human neoplasm. The disease is derived…
Definition Nodal marginal zone lymphoma (NMZL) is a primary nodal B-cell neoplasm derived from post–germinal center B cells. This lymphoma shares morphologic and immunophenotypic similarities with other marginal zone lymphomas, particularly extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue…
Historical Background The classification of lymphoid neoplasms used in this text is the one published by the World Health Organization (WHO) in WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues . Initially published in 2008, the WHO's fourth edition…
Lymphoid tissues are the sites where precursor cells mature into immunocompetent lymphoid cells and where immune reactions to antigens occur. The lymphoid tissues and the stages of lymphocyte differentiation and maturation have an anatomy—they occur at specific sites in the…