Anemia, polycythemia, and functional derangements of the human erythrocyte together represent a common group of human disorders with a significant impact on public health. Sickle cell disease, hemoglobin E (HbE)–associated disorders, and the thalassemias are humankind’s most common single-gene diseases,…
Normal blood cells have limited life spans; they must be replenished in precise numbers by a continuously renewing population of progenitor cells. Homeostasis of the blood requires that proliferation of these cells be efficient yet strictly constrained. Many distinctive types…
Anemia, polycythemia, and functional derangements of the human erythrocyte together represent a common group of human disorders with a significant impact on public health. Sickle cell disease, hemoglobin E (HbE)–associated disorders, and the thalassemias are humankind’s most common single-gene diseases,…
Normal blood cells have limited life spans; they must be replenished in precise numbers by a continuously renewing population of progenitor cells. Homeostasis of the blood requires that proliferation of these cells be efficient yet strictly constrained. Many distinctive types…