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Laboratory investigation of a suspected inherited platelet disorder (IPD) requires both standard and confirmatory platelet laboratory testing. The former includes platelet count, mean platelet volume and other indices by a hematology analyzer, peripheral blood smear review by light microscopy, and…

▪ Introduction Mast cells (MCs) were initially recognized in 1878 by Paul Ehrlich, a Nobel laureate in immunology. They are unique inflammatory mediator cells that contain distinctive metachromatic and electron-dense cytoplasmic granules. MCs derive from bone marrow pluripotent hematopoietic progenitors.…