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Key Points Dual-antiplatelet therapy (DAPT) with aspirin and a P2Y 12 receptor inhibitor is the cornerstone of therapy after percutaneous coronary intervention (PCI) with stents. The thienopyridines—ticlopidine, clopidogrel, and prasugrel—are P2Y 12 inhibitors that are prodrugs and therefore require conversion…
Introduction Atherosclerotic plaque rupture followed by arterial thrombosis is the major determinant that leads to an acute coronary syndrome (ACS). Platelet adhesion, activation, and aggregation have a pivotal role in the cascade of events that lead to arterial thrombosis, and…