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Only a little more than 30 years ago a popular, widely used classification system for non-Hodgkin lymphomas (NHLs) was initiated based solely on hematoxylin and eosin (H&E)–stained slide interpretation. The “Working Formulation for Clinical Usage” was used for over a…

Overview The hematologic system is complex and includes a diverse range of organs, including the bone marrow, spleen, and lymph nodes. Lymph node disease is covered in Chapter 6 . In this chapter, immunohistochemical evaluation of the bone marrow, spleen,…